Acquired Resistance to Corticotropins

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Acquired resistance to corticotropins.

Corticotropin, which may be defined as a pituitary extract that will directly stimulate the adrenal cortex to secrete its predominantly "glucocorticoid" hormones, has been in general use for about 5 years. In spite of this, its use as a therapeutic agent has not been defined. There are two reasons for this state of affairs. The first is that most physicians have assumed that the administration ...

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Purified alpha-corticotropin has been reported to exercise the following biological effects: (a) stimulation of the adrenal glands in normal and hypophysectomized rats, (b) production of blood eosinopenia in hypophysectomized rats, (c) maintenance of muscle glycogen in hypophysectomized rats, (d) inhibition of growth-promoting activity of somatotropin, (e) stimulation of melanocytes in the skin...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1956

ISSN: 0003-4967

DOI: 10.1136/ard.15.2.124